Local Anaesthetics Combined with Vasoconstrictors in Controlled Hypertensive Patients Undergoing Dental Procedures: Systematic Review and Meta-Analysis

The aim of this systematic review is to assess the safety local anaesthetics (LA) combined with vasoconstrictors (VC) for patients controlled hypertension undergoing dental procedures. A comprehensive search strategy were used identify all relevant randomized trials (RCTs) that evaluated effect LA VC. All searches covered period from 1990 February 2021. We performed a meta-analysis using random-effect models and assessed overall certainty in evidence GRADE approach. Our yielded 1262 references. Finally, seven randomised included, but only three included meta-analysis. use VC may result little no difference heart rate (HR), systolic blood pressure (SBP) diastolic (DBP), was as low. Death, stroke, acute myocardial infarction, need hospitalization, pain bleeding not reported by studies. hemodynamic changes do imply an increased risk occurrence adverse cardiovascular events. could even be recommendable considering their multiple advantages.